ECO-Logic Reactions: Shaping the Future of Sustainable Molecular Science

Authors

  • Arshiya Aqsa Syed KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
  • Challa Maruthi Santhosh KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
  • Majji Murali Krishna KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
  • Umme Kulsum KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
  • A. Suneetha KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
  • Patibandla Jahnavi KVSR Siddartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.

Abstract

In the era of environmental urgency, chemistry is undergoing a profound transformation—from efficiency-focused innovation to sustainability-centered solutions. This review explores the concept of eco-logic reactions, a progressive branch of molecular science that merges synthetic efficiency with ecological mindfulness. Rooted in the 12 principles of green chemistry, these reactions prioritize atom economy, non-toxic reagents, energy conservation, and minimal waste production. The manuscript highlights key eco-conscious innovations such as biocatalysis, organocatalysis, photocatalysis, and solvent-free reactions, offering practical examples that illustrate the shift from traditional practices toward cleaner and safer methodologies. Particular attention is given to solvent engineering, renewable feedstocks, and circular chemistry, emphasizing how the use of biomass, CO₂ utilization, and waste-to-chemical processes redefine sustainability in labs and industries. Moreover, the review discusses process intensification strategies like flow chemistry, mechanochemistry, and the integration of AI/ML for reaction optimization. Greenness metrics and life cycle assessments are also explored as tools to quantify and compare eco-efficiency. Applications in drug discovery, polymer science, and material innovation show how eco-logic principles are revolutionizing real-world production while aligning with global environmental goals. Additionally, regulatory support, educational integration, and collaborative frameworks are emphasized as vital drivers for mainstream adoption. This review aims to serve as a roadmap for chemists, educators, and policymakers invested in advancing a cleaner, smarter, and more sustainable future through the lens of eco-logic chemistry.

Keywords:

Eco-logic reactions, green chemistry, Sustainable catalysis, Renewable feedstocks, Solvent engineering, Life cycle assessment

DOI

https://doi.org/10.37022/wjcmpr.v7i2.359

References

1. Anastas PT, Warner JC. Green Chemistry: Theory and Practice. Oxford University Press; 1998.

2. Sheldon RA. Atom efficiency and catalysis in organic synthesis. Pure Appl Chem. 2000;72(7):1233–1246.

3. Tundo P, Anastas P, Black D, Breen J, Collins T, Memoli S, et al. Synthetic pathways and processes in green chemistry. Intro Green Chem. 2000;2(1):115–124.

4. Poliakoff M, Fitzpatrick JM, Farren TR, Anastas PT. Green chemistry: Science and politics of change. Science. 2002;297(5582):807–810.

5. Horváth IT. A green chemistry perspective on catalysis. Chem Rev. 2007;107(6):2169–2173.

6. Jessop PG. Searching for green solvents. Green Chem. 2011;13(6):1391–1398.

7. Li CJ. Organic reactions in aqueous media with a focus on carbon-carbon bond formations: a decade update. Chem Rev. 2005;105(8):3095–3165.

8. Kerton FM. Alternative Solvents for Green Chemistry. RSC Publishing; 2009.

9. Clark JH, Macquarrie DJ. Handbook of Green Chemistry and Technology. Blackwell Science; 2002.

10. Tanaka K. Solvent-Free Organic Synthesis. 2nd ed. Wiley-VCH; 2009.

11. Sheldon RA. E factors, green chemistry and catalysis: An odyssey. Chem Commun. 2008;(29):3352–3365.

12. Chemat F, Rombaut N, Sicaire AG, Meullemiestre A, Fabiano-Tixier AS, Abert-Vian M. Ultrasound assisted extraction of food and natural products. Ultrason Sonochem. 2017;34:540–560.

13. Li CJ, Trost BM. Green chemistry for chemical synthesis. Proc Natl Acad Sci U S A. 2008;105(36):13197–13202.

14. Azócar L, Ciudad G, Heipieper HJ, Navia R. Biocatalytic processes for the production of green fuels and chemicals. Biotechnol J. 2010;5(3):307–314.

15. Pericas MA, Vidal-Ferran A, Masdeu-Bultó AM. Recyclable catalytic systems. Chem Rev. 2004;104(9):4151–4202.

16. Colmenares JC, Luque R. Heterogeneous photocatalysis in green chemical processes. Chem Soc Rev. 2014;43(3):765–778.

17. Zeng J, Lin L, Yan Y. Electrochemical conversion of CO₂ to fuels: progress and challenges. Green Chem. 2018;20(18):4399–4410.

18. Kappe CO. Controlled microwave heating in modern organic synthesis. Angew Chem Int Ed Engl. 2004;43(46):6250–6284.

19. Tan B, Hernández-Torres G, Barbas CF III. Organocatalysis: Enantioselective reactions in green solvents. Chem Eur J. 2012;18(45):14258–14262.

20. Martins S, Silva R, Nunes FM, Silva CM. Deep eutectic solvents as alternative media for extraction and chemical reactions. J Mol Liq. 2019;294:111666.

21. Jessop PG, Ikariya T, Noyori R. Supercritical carbon dioxide as a reaction medium. Chem Rev. 1999;99(2):475–493.

22. Chaturvedi V, Verma P. Biotechnological approaches for the production of biofuels using lignocellulosic biomass. Biofuel Res J. 2013;1(1):7–20.

23. Werner T, Meiners F, Meiners T. Mechanochemistry as an efficient tool for green chemistry. Green Chem Lett Rev. 2014;7(3):259–269.

24. Koenig SG, Jorgensen WL. Life cycle assessment of pharmaceutical manufacturing: a case study. Org Process Res Dev. 2010;14(5):1010–1018.

25. Constable DJC, Curzons AD, Cunningham VL. Metrics to ‘green’ chemistry—Which are the best? Green Chem. 2002;4(6):521–527.

26. Pokorska J, Shulga Y, Cacciò D, et al. Green metrics for the development of sustainable synthetic methods. Curr Opin Green Sustain Chem. 2018;11:29–34.

27. Egorova KS, Ananikov VP. Toxicity of ionic liquids: Eco(cyto)activity as complicated, but unavoidable parameter for task-specific optimization. ChemSusChem. 2014;7(2):336–360.

28. Dicks AP, Hent A. Green Chemistry Education: Changing the Course of Chemistry. ACS Publications; 2014.

29. Haider TZ, Bevilacqua A. Digitalization in green chemistry: AI and machine learning for sustainable synthesis. Green Chem. 2022;24(3):915–930.

30. Huang Y, Tang L, Zhang Q. Circular economy in the chemical industry: Transforming waste to resources. Curr Opin Chem Eng. 2021;31:100672.

31. Blackmond DG. "If pigs could fly" chemistry: rational design of greener processes. Phil Trans R Soc A. 2007;365(1850):1529–1541.

32. Lancet T. The Safer Choice Program of the U.S. Environmental Protection Agency. Lancet Planet Health. 2021;5(3):e109.

33. Li Z, Zhang X, Chen J. Recent advances in green polymer chemistry. Macromol Rapid Commun. 2020;41(10):1900641.

Published

2025-07-17
Statistics
Abstract Display: 192
PDF Downloads: 119
Dimension Badge

How to Cite

1.
ECO-Logic Reactions: Shaping the Future of Sustainable Molecular Science. World Journal of Current Med and Pharm Research [Internet]. 2025 Jul. 17 [cited 2025 Oct. 25];7(2):7-11. Available from: http://wjcmpr.org/index.php/journal/article/view/359

Issue

Section

Review Articles

How to Cite

1.
ECO-Logic Reactions: Shaping the Future of Sustainable Molecular Science. World Journal of Current Med and Pharm Research [Internet]. 2025 Jul. 17 [cited 2025 Oct. 25];7(2):7-11. Available from: http://wjcmpr.org/index.php/journal/article/view/359