A study on the effectiveness of various treatment approaches for bronchiolitis

Authors

  • Rangam Charitha Assistant Professor, Department of Pharmacology, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Ettae Vydehi Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Maviya Sultana Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Raheen Madiha Manzoor Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Sumaiya Sultana Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Afreen Khatoon Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.
  • Nabeela Nousheen Pharm. D V year, Smt. Sarojini Ramulamma College of Pharmacy, (Palamuru University), Seshadri Nagar, Mahabubnagar District, Telangana State, India.

Abstract

Bronchiolitis is a major cause of hospitalisation in infants, and its management varies widely across clinical settings. This observational study, conducted at SVS Medical College & Hospital over six months with 80 patients, assessed treatment patterns and outcomes. Bronchiolitis was most common in infants aged 5–8 months, with a higher incidence in males and rural populations, and mild disease was predominant. Treatment showed significant variation: intravenous fluids, especially dextrose normal saline with potassium supplementation, were frequently used to maintain hydration and electrolyte balance; parenteral antibiotics such as Augmentin were selectively administered when bacterial infection was suspected; and oral therapies including paracetamol, ambroxol, and vitamin D3 drops provided symptomatic relief. Saline nasal drops were universally prescribed, highlighting their essential role in airway clearance, while nebulised budesonide and salbutamol were used occasionally depending on severity. Heated Humidified High-Flow Nasal Cannula (HHHFNC) therapy was identified as the main supportive intervention, enhancing oxygenation and reducing respiratory distress. Overall, the combination of parenteral fluids, oral medications, nasal saline drops, and supportive care led to shorter hospital stays and quicker recovery, whereas reliance solely on supportive care and saline drops without targeted therapies was associated with extended hospitalisation. These findings emphasise the importance of integrated, evidence-based management strategies in bronchiolitis.

Keywords:

Bronchiolitis, Respiratory Syncytial Virus (RSV), Intravenous fluids, Heated Humidified High-Flow Nasal Cannula (HHHFNC), Supportive care, Corticosteroids, Bronchodilators

DOI

https://doi.org/10.37022/wjcmpr.v7i2.367

References

1. Justice NA, Le JK. Bronchiolitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441959/

2. Polack FP, Stein RT, Custovic A. The syndrome we agreed to call bronchiolitis. J Infect Dis. 2019;220(2):184-6.

3. Oz-Alcalay L, Ashkenazi S, Glatman-Freedman A, Weisman-Demri S, Lowenthal A, Livni G. Hospitalization for RSV bronchiolitis in the palivizumab prophylaxis era: reconsideration of preventive timing and eligibility. Isr Med Assoc J. 2019;21(2):110-5.

4. Soudani N, Caniza MA, Assaf-Casals A, Shaker R, Lteif M, Tang L, et al. Prevalence and characteristics of acute respiratory virus infections in pediatric cancer patients. J Med Virol. 2019;91(7):1191-201.

5. Jhawar S. Severe bronchiolitis in children. Clin Rev Allergy Immunol. 2003;25(3):249-57.

6. Lodeserto FJ, Lettich TM, Rezaie SR. High-flow nasal cannula: mechanisms of action and pediatric indications. Cureus. 2018;10(11):e3639.

7. Clayton JA, McKee B, Slain KN, Rotta AT, Shein SL. Outcomes of children with bronchiolitis treated with high-flow nasal cannula or noninvasive ventilation. Pediatr Crit Care Med. 2019;20(2):128-35.

8. Supino MC, Buonsenso D, Scateni S, Scialanga B, Mesturino MA, Bock C, et al. Point-of-care lung ultrasound in infants with bronchiolitis in the pediatric emergency department. Eur J Pediatr. 2019;178(5):623-32.

9. Zar HJ, Ferkol TW. The global burden of respiratory disease: impact on child health. Pediatr Pulmonol. 2014;49(5):430-4.

10. Cahill AA, Cohen J. Improving evidence-based bronchiolitis care. Clin Pediatr Emerg Med. 2018;19(1):33-9.

11. Florin TA, Plint AC, Zorc JJ. Viral bronchiolitis. Lancet. 2017;389(10065):211-24.

12. Nicolai A, Ferrara M, Schiavariello C, Gentile F, Grande ME, Alessandroni C, et al. Viral bronchiolitis in children: a common condition with few therapeutic options. Early Hum Dev. 2013;89(Suppl 3):S7-11.

13. Kua KP, Lee SW. Complementary and alternative medicine for bronchiolitis in infants: a systematic review. PLoS One. 2017;12(2):e0172289.

14. Ambrożej D, Makrinioti H, Whitehouse A, Papadopoulos N, Ruszczyński M, Adamiec A, et al. Respiratory virus type to guide predictive enrichment approaches in bronchiolitis. Front Immunol. 2022;13:1017325.

15. Hasegawa K, Dumas O, Hartert TV, Camargo CA Jr. Advancing understanding of infant bronchiolitis through phenotyping and endotyping. Expert Rev Respir Med. 2016;10(8):891-9.

16. Krishna D, Khera D, Toteja N, Sureka B, Choudhary B, Ganakumar VM, et al. Point-of-care thoracic ultrasound in children with bronchiolitis. Indian J Pediatr. 2022;89(11):1079-85.

17. Kern-Goldberger AS, Rasooly IR, Luo B, Craig S, Ferro DF, Ruppel H, et al. EHR-integrated monitor data to measure pulse oximetry use in bronchiolitis. Hosp Pediatr. 2021;11(10):1073-82.

18. Carlone G, Graziano G, Trotta D, Cafagno C, Aricò MO, Campodipietro G, et al. Bronchiolitis 2021–2022 epidemic: multicentric analysis in 214 children from Italy. Eur J Pediatr. 2023;182(4):1921-7.

19. Winer JC, Richardson T, Berg KJ, Berry J, Chang PW, Etinger V, et al. Effect modifiers of the association of high-flow nasal cannula and bronchiolitis length of stay. Hosp Pediatr. 2023;13(11):1018-27.

20. Bastos JCS, Simas PVM, Caserta LC, Bragunde AEA, Marson FAL, Martini MC, et al. Rhinoviruses as critical agents in severe bronchiolitis in infants. J Pediatr (Rio J). 2022;98(4):362-8.

21. Fujiogi M, Goto T, Yasunaga H, Fujishiro J, Mansbach JM, Camargo CA Jr, et al. Trends in bronchiolitis hospitalizations in the United States: 2000–2016. Pediatrics. 2019;144(6):e20192614.

22. Manti S, Staiano A, Orfeo L, Midulla F, Marseglia GL, Ghizzi C, et al. 2022 Italian guidelines on management of bronchiolitis in infants. Ital J Pediatr. 2023;49(1):19.

23. Porcaro F, Cutrera R, Vittucci AC, Villani A. Bronchiolitis guidelines in Italian primary care: a pediatric perspective. Ital J Pediatr. 2023;49(1):123.

24. Jartti T, Smits HH, Bønnelykke K, Bircan O, Elenius V, Konradsen JR, et al. Bronchiolitis needs a revisit: distinguishing between virus entities and treatments. Allergy. 2019;74(1):40-52.

25. Sieminska A, Kuziemski K. Respiratory bronchiolitis-interstitial lung disease. Orphanet J Rare Dis. 2014;9:106.

26. Florin TA, Zorc JJ. Evidence-based management of bronchiolitis. Lancet Child Adolesc Health. 2022;6(2):86-96.

27. Ambrożej D, Makrinioti H, Whitehouse A, Papadopoulos N, Ruszczyński M, et al. Virus-specific approaches in bronchiolitis. Front Immunol. 2022;13:1017325.

28. Justice NA, Le JK. Bronchiolitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.

29. Florin TA, Plint AC, Zorc JJ. Viral bronchiolitis. Lancet. 2017;389:211-24.

30. Supino MC, Buonsenso D, Scateni S, Scialanga B, Mesturino MA, Bock C, et al. Lung ultrasound in bronchiolitis. Eur J Pediatr. 2019;178(5):623-32.

31. Clayton JA, McKee B, Slain KN, Rotta AT, Shein SL. HFNC vs NIV in bronchiolitis. Pediatr Crit Care Med. 2019;20(2):128-35.

32. Carlone G, Graziano G, Trotta D, Cafagno C, Aricò MO, Campodipietro G, et al. Bronchiolitis epidemic 2021–2022: Italian analysis. Eur J Pediatr. 2023;182(4):1921-7.

33. Krishna D, Khera D, Toteja N, Sureka B, Choudhary B, Ganakumar VM, et al. Thoracic ultrasound in bronchiolitis. Indian J Pediatr. 2022;89(11):1079-85.

34. Hasegawa K, Dumas O, Hartert TV, Camargo CA Jr. Infant bronchiolitis phenotyping. Expert Rev Respir Med. 2016;10(8):891-9.

35. Manti S, Staiano A, Orfeo L, Midulla F, Marseglia GL, Ghizzi C, et al. Italian guidelines on bronchiolitis. Ital J Pediatr. 2023;49:19.

36. Zar HJ, Ferkol TW. Global burden of respiratory disease in children. Pediatr Pulmonol. 2014;49(5):430-4.

37. Jhawar S. Severe bronchiolitis in children. Clin Rev Allergy Immunol. 2003;25:249-57.

38. Kua KP, Lee SW. CAM for bronchiolitis in infants: systematic review. PLoS One. 2017;12(2):e0172289.

Published

2025-08-31
Statistics
Abstract Display: 37
PDF Downloads: 21
Dimension Badge

How to Cite

1.
A study on the effectiveness of various treatment approaches for bronchiolitis. World Journal of Current Med and Pharm Research [Internet]. 2025 Aug. 31 [cited 2025 Sep. 22];7(2):44-9. Available from: http://wjcmpr.org/index.php/journal/article/view/367

Issue

Section

Research Articles

How to Cite

1.
A study on the effectiveness of various treatment approaches for bronchiolitis. World Journal of Current Med and Pharm Research [Internet]. 2025 Aug. 31 [cited 2025 Sep. 22];7(2):44-9. Available from: http://wjcmpr.org/index.php/journal/article/view/367