COMPARATIVE EVALUATION OF LACTOBACILLUS SALIVARIUS PROBIOTIC GEL AND CHLORHEXIDINE GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE MANAGEMENT OF CHRONIC PERIODONTITIS: A RANDOMIZED CLINICAL STUDY
Abstract
Aim: To evaluate and compare the efficacy of probiotic gel containing Lactobacillus salivarius and chlorhexidine gel as adjunct to scaling and root planing in patients with chronic periodontitis.
Materials and Methods: Group I (n = 24) received scaling and root planing (SRP) followed by local application of Lactobacillus salivarius probiotic gel, while Group II (n = 24) received SRP followed by chlorhexidine gel. Clinical parameters, including plaque index, sulcular bleeding index, probing pocket depth, and clinical attachment level, were recorded at baseline and after 3 months. Intragroup and intergroup comparisons were performed using appropriate statistical tests, with statistical significance set at p < 0.05.
Results: Intragroup comparison showed significant improvement in all clinical parameters at 3 months (p < 0.05). Intergroup comparison at 3 months showed significantly lower PPD and CAL in the probiotic group (p < 0.05), while PI and SBI were comparable (p > 0.05).
Conclusion: Probiotic gel containing Lactobacillus salivarius used as an adjunct to SRP demonstrated superior clinical improvement in probing pocket depth and clinical attachment levels compared to chlorhexidine gel.
Keywords:
Chronic periodontitis, Probiotics, Lactobacillus salivarius, Chlorhexidine gel, Scaling and root planningDOI
https://doi.org/10.37022/wjcmpr.v8i1.393References
1. Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza’s Clinical Periodontology. 13th ed. St. Louis: Elsevier; 2019.
2. Marsh, P.D. Dental plaque as a biofilm and a microbial community – implications for health and disease. BMC Oral Health 6 (Suppl 1), S14 (2006). https://doi.org/10.1186/1472-6831-6-S1-S14
3. Isola G, Polizzi A, Santonocito S, Alibrandi A, Pesce P, Kocher T. Effect of quadrantwise versus full-mouth subgingival instrumentation on clinical and microbiological parameters in periodontitis patients: A randomized clinical trial. J Periodont Res. 2024;59:647-656. doi:10.1111/jre.13279
4. Addy M, Moran JM. Clinical indications for the use of chemical adjuncts to plaque control: chlorhexidine formulations. Periodontol 2000. 1997 Oct;15:52-4. doi: 10.1111/j.1600-0757.1997.tb00104.x. PMID: 9643232.
5. Löe H, Schiott CR. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res. 1970;5(2):79-83. doi: 10.1111/j.1600-0765.1970.tb00696.x. PMID: 4254172.
6. Gupta G. Probiotics and periodontal health. J Med Life. 2011 Nov 14;4(4):387-94. Epub 2011 Nov 24. PMID: 22514571; PMCID: PMC3227153.
7. El-Bagoory GK, El-Guindy HM, Shoukheba MY, El-Zamarany EA. The adjunctive effect of probiotics to nonsurgical treatment of chronic periodontitis: a randomized controlled clinical trial. J Indian Soc Periodontol. 2021;25(6):525–531. doi:10.4103/jisp.jisp_114_21.
8. Teughels, W., Van Essche, M., Sliepen, I. and Quirynen, M. (2008), Probiotics and oral healthcare. Periodontology 2000, 48: 111-147. https://doi.org/10.1111/j.1600-0757.2008.00254.x
9. Stamatova, I. and Meurman, J.H. (2009), Probiotics and periodontal disease. Periodontology 2000, 51: 141-151. https://doi.org/10.1111/j.1600-0757.2009.00305.x
10. Allaker, R.P., Stephen, A.S. Use of Probiotics and Oral Health. Curr Oral Health Rep 4, 309–318 (2017). https://doi.org/10.1007/s40496-017-0159-6
11. Remington: The Science and Practice of Pharmacy. 21st ed. Philadelphia: Lippincott Williams & Wilkins; 2005.
12. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines. 5th ed. Elsevier; 2018.
13. Löe, H. (1967), The Gingival Index, the Plaque Index and the Retention Index Systems. The Journal of Periodontology, 38: 610-616. https://doi.org/10.1902/jop.1967.38.6_part2.610
14. Pihlstrom, B.L. (1992), Measurement of Attachment Level in Clinical Trials: Probing Methods. Journal of Periodontology, 63: 1072-1077. https://doi.org/10.1902/jop.1992.63.12s.1072
15. Mühlemann HR, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helv Odontol Acta. 1971 Oct;15(2):107-13. PMID: 5315729.
16. Quirynen M, Bollen CM, Vandekerckhove BN, Dekeyser C, Papaioannou W, Eyssen H. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res. 1995 Aug;74(8):1459-67. doi: 10.1177/00220345950740080501. PMID: 7560400.
17. Gunjal S, Hampiholi V, Ankola AV, Pateel DGS. Comparison of the effectiveness of Morus alba and chlorhexidine gels as an adjunct to scaling and root planing on stage II periodontitis - A randomized controlled clinical trial. Int J Dent Hyg. 2024 Aug;22(3):717-726. doi: 10.1111/idh.12781. Epub 2024 Jan 15. PMID: 38225885.
18. Hasan F, Ikram R, Adel A, Abbas A, Ain Bukhari QU, Asadullah K. Treatment of periodontal diseases by the local drug delivery system using 1% chlorhexidine gel: A randomized clinical trial. Pak J Pharm Sci. 2021 Jan;34(1):41-45. PMID: 34248001.
19. Kõll-Klais P, Mändar R, Leibur E, Marcotte H, Hammarström L, Mikelsaar M. Oral lactobacilli in chronic periodontitis and periodontal health: species composition and antimicrobial activity. Oral Microbiol Immunol. 2005 Dec;20(6):354-61. doi: 10.1111/j.1399-302X.2005.00239.x. PMID: 16238595.
20. Kõll P, Mändar R, Marcotte H, Leibur E, Mikelsaar M, Hammarström L. Characterization of oral lactobacilli as potential probiotics for oral health. Oral Microbiol Immunol. 2008 Apr;23(2):139-47. doi: 10.1111/j.1399-302X.2007.00402.x. PMID: 18279182.
21. Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol. 2008 Oct;35(10):897-905. doi: 10.1111/j.1600-051X.2008.01306.x. Epub 2008 Aug 24. PMID: 18727656.
22. Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, Shimauchi H. Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol. 2009 Jun;36(6):506-13. doi: 10.1111/j.1600- 051X.2009.01392.x. Epub 2009 Apr 22. PMID: 19453574.
23. Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, Hirata H. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol. 2008 Oct;35(10):897-905. doi: 10.1111/j.1600-051X.2008.01306.x. Epub 2008 Aug 24. PMID: 18727656.
24. Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Aug; 110(2):201-8. doi: 10.1016/j.tripleo.2010.03.032. PMID: 20659698.
25. Saïz, P., Taveira, N., & Alves, R. (2021). Probiotics in oral health and disease: A systematic review. Applied Sciences (Switzerland), 11(17), Article 8070.https://doi.org/10.3390/app11178070
26. Butera A, Gallo S, Maiorani C, et al. Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters. Microorganisms. 2020 Dec;9(1):E69. DOI: 10.3390/ microorganisms9010069. PMID: 33383903; PMCID: PMC7824624.
27. Vishnusripriya J, Melath A, Feroz M, Subair K, Chandran N. Comparative evaluation of locally delivered probiotic paste and chlorhexidine gel as an adjunct to scaling and root planing in treating chronic periodontitis: A split- mouth randomized clinical trial. J Indian Soc Periodontol. 2022 May-Jun;26(3):262-268.
doi: 10.4103/jisp.jisp_704_20. Epub 2022 May 2. PMID: 35602526; PMCID: PMC9118933.
28. NĘdzi-GÓra M, WrÓblewska M, GÓrska R. The Effect of Lactobacillus salivarius SGL03 on Clinical and Microbiological Parameters in Periodontal Patients. Pol J Microbiol. 2020 Dec;69(4):441-451. doi: 10.33073/pjm- 2020-047. Epub 2020 Nov 27. PMID: 33574872; PMCID: PMC7812367.
29. Alahari, Swetha, et al. "Effect of Probiotic Mouthwashes in Comparison to Chlorhexidine on Periodontal Health: Systematic Review and Meta-analysis." International Journalof Health Sciences, vol. 6, no. S9, 2022, pp. 2213- 2228,doi:10.53730/ijhs.v6nS9.12905.
Published
Abstract Display: 24
PDF Downloads: 17 How to Cite
Issue
Section

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

