FORMULATION AND EVALUATION OF IBUPROFEN AND CHLORZOXAZONE SUSPENSION USING NATURAL AND SYNTHETIC SUSPENDING AGENTS
Abstract
The present study was undertaken to formulate and evaluate an oral suspension of Ibuprofen and Chlorzoxazone using natural and synthetic suspending agents, with the objective of comparing their influence on physicochemical properties and suspension stability. Ibuprofen, a non-steroidal anti-inflammatory drug, and Chlorzoxazone, a centrally acting muscle relaxant, are widely prescribed in musculoskeletal disorders but exhibit poor aqueous solubility, making suspension formulation a suitable approach for improving patient compliance. Four formulations (F1–F4) were prepared by the trituration method using methylcellulose as a synthetic suspending agent and fenugreek (Trigonella foenum-graecum) seed powder as a natural suspending agent at different concentrations. Preformulation studies, including melting point determination and FTIR spectroscopy, confirmed the identity and purity of both drugs. The prepared suspensions were evaluated for particle size, sedimentation volume, viscosity, flow rate, pH, swelling index, and phytochemical characteristics. Among the formulations, F2 exhibited the highest viscosity and sedimentation volume with the lowest flow rate, indicating superior physical stability, while F4 demonstrated acceptable stability with improved homogeneity using a natural suspending agent. All formulations showed pH values within an acceptable range for oral administration. The swelling index and phytochemical screening confirmed the presence of mucilage and other bioactive constituents in fenugreek seed powder, supporting its role as an effective natural suspending agent. The study demonstrates that natural suspending agents can serve as promising alternatives to synthetic polymers in suspension formulations.
Keywords:
Ibuprofen, Chlorzoxazone, Oral suspension, Fenugreek seed powder, Methylcellulose, Natural suspending agentDOI
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